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Research Highlights

Hundreds of scientists working at Cold Spring Harbor Laboratory contribute research published in major research journals, in the fields of Cancer, Neuroscience, Plant Biology, Quantitative Biology, and Genomics.

Long-sought mechanism of metastasis is discovered in pancreatic cancer

7/27/2017

An epigenetic factor reprograms gene enhancers, enabling cancer cells to “remember” an earlier developmental state and causing metastasis. Read the story »

Freeze-frames of enzymes in action have implications for a new cancer treatment concept

7/3/2017

TUTase enzymes interact with let-7, a regulator of development; targeting them could help control certain cancers. Read the story »

Newly identified small RNA fragments defend the genome when it’s ‘naked’

6/29/2017

Fragments snipped from tRNAs protect embryonic stem cells while they’re being epigenetically reprogrammed. Read the story »

Detailed new ‘reference’ genome for maize shows the plant has deep resources for continued adaptation

6/12/2017

A new, much more detailed reference genome for maize, or corn, as it is called in the U.S., provides new insight into the crop. Read the story »

Protein complex that takes first steps in human DNA replication dance is captured at high atomic resolution

3/16/2017

Human ORC complex captured in action in x-ray crystallography and cryo-EM Read the story »

Dopamine neurons factor ambiguity into predictions that enable us to “win big and win often”

3/9/2017

Researchers describe how dopamine-releasing neurons weigh the ambiguity of sensory information, indicating that neurons are highly sophisticated. Read the story »

Discovery of distinct cell subtypes around tumors helps explain why pancreatic cancer is so hard to treat

2/23/2017

Researchers finds that stroma,“wound”-like tissue that surrounds the tumors, helps explain why pancreatic cancer is so resistant to treatment. Read the story »

Researchers identify “Achilles’ heel” of PTEN that helps drive prostate cancer progression

2/13/2017

Researchers at CSHL have discovered that a protein called Importin-11 protects the anti-cancer protein PTEN from destruction by transporting it. Read the story »

Relationship between incorrect chromosome number and cancer is reassessed after surprising experiments

1/12/2017

Pre-malignant aneuploid cells grew more slowly and formed smaller tumors than comparable cells with normal chromosome number, CSHL researchers found. Read the story »

Gene editing yields tomatoes that flower and ripen weeks earlier

12/5/2016

Researchers use CRISPR to expand the geographical range of important food crops. Read the story »

Detailed images of NMDA receptor show how zinc and a potential drug affect its function

12/1/2016

Drugs precisely targeting portions of the NMDA receptor may have applications in Alzheimer’s, depression and schizophrenia. Read the story »

Focus on quiescent cells brings to light the essential role of RNA interference in transcription control

11/9/2016

RNAi and other epigenetic processes induce changes in where and when specific genes are expressed without altering their genetic code. Read the story »

Pancreas and colon tumors reprogram the liver, causing wasting and short-circuiting body’s immune response

11/8/2016

Research reveals a mechanism that causes wasting in cancer and tests a way to reverse it. Read the story »

Our most common infection-fighting white blood cells can be hijacked to support cancer spread

10/19/2016

Neutrophils, the most common type of white blood cell, can be taken over by cancer cells and used as an aid in metastasis. Read the story »

Non-coding portions of genome are found to play role in cancer

9/27/2016

CSHL scientists test an antisense method of targeting long noncoding RNAs overexpressed in breast cancers. Read the story »

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